Diabetic Complications
There are five aspects that need to be considered in therapy for diabetic complications. Hyperglycemia needs to be controlled as well as possible.
- Free radical production in hyperglycemia needs to be quenched.
- The polyol pathway in which excess sugar alcohols are produced needs to be inhibited.
- The organs that are affected, such as the eyes, kidneys, and nerves, need to be supported.
- Protein glycosylation needs to be inhibited.
Inihibiting Polyol Pathway and Free Radical Formation
- Quercitin: 2 g daily
- Vitamin C: 2 g daily
- IV Gluatahione: 100 mg daily
- Grape seed extract: 100 mg daily
Inhibiting Protein Glycosylation and Decreasing Polyol Formation
- Lipoic Acid: 200-500 mg daily
- Quercitin: 1-2 g daily
- Vitamin E: 400-12000 IU daily
Secondary Diabetic Complications Botanicals and Nutraceuticals
| Herb/Nutrient | Action | Dose |
| Silybum marianum (Milk Thistle) | AntioxidantReduces aldose reductase | 1 g daily |
| Hypericum perforatum(St. John’s Wort) | Aids in neuropathy, both internally and externally | 1 g daily |
| Eupatorium purpureum(Gravel Root) | Aids in kidney function | 1 g daily |
| Solidago canadensis(Canadian Goldenrod) | Aids in kidney function | 1 g daily |
| Vaccinum myrtillus(Bilberry) | Aids in eye function | 1 g daily |
| Syzygium jambolana(Jambul Seed) | Antioxidant | 1 g daily |
| Inositol | Replenishes inositol depletion from hyperglycemia induced sorbitol osmosis causing inositol excretion | 2 g daily |
| Vitamin B-6 | Aids in neuropathy | 100 mg daily |
| Vitamin B-12 | Aids in neuropathy | 1000 mcg daily |
| CoQ10 | Aids in cardiac function | 500 mg daily |
| Cereus grandiflorus(Night Blooming Cactus) | Aids in cardiac function | 10 drops twice daily |
| Convallaria officinalis(Lily of the Valley) | Aids in cardiac function | 10 drops twice daily |
| Crataegus oxycantha(Hawthorne) | Aids in cardiac function | 60 drops twice daily |
| Leonurus cardiaca(Motherwort) | Aids in cardiac function | 60 drops twice daily |
| Pelargonium spp.(Geranium Oil) | Topical treatment for neuropathy (pain relief immediate but temporary) | topical |
| Aminoguanidine | Decreases advanced glycosylation end productsDecreases advanced glycosylation end products | 300 mg twice daily |
| Alpha tocopherol nicotinate | Improves blood rheology, decreases lipid peroxidation | 300 mg twice daily |
| Ganoderma lucidum(Reishi) | Increases nitric oxide | 1 g daily |
| Quercitin | Reduces aldose reductase | 1 g daily |
| Anthocyanins | Increases capillary strength | 180-215 mg daily |
| Green Tea Catechins | Increases capillary strength | 400 mg-1 g daily |
